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Showing 1–13 of 13 results
Advanced filters: Author: "Elisabetta Dejana" Clear advanced filters

  • Cerebral cavernous malformations associated with loss of function of Ccm1 are shown to be formed by endothelial cells undergoing endothelial-to-mesenchymal transition (EndMT) induced by TGF-β and BMP signalling; inhibition of TGF-β and BMP signalling prevents EndMT and the appearance of CCM lesions.

    • Luigi Maddaluno
    • Noemi Rudini
    • Elisabetta Dejana
    Research
    Nature
    Volume: 498, P: 492-496

  • The alternative splicing factor Nova2 is best known for its pivotal function in the brain. Giampietro et al. reveal an important role for Nova2 in the regulation of alternative splicing of transcripts in the vascular endothelium that are crucial for the maintenance of endothelial cell polarity and vessel lumen formation in zebrafish.

    • Costanza Giampietro
    • Gianluca Deflorian
    • Claudia Ghigna
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-15

  • Cerebral cavernous malformation is a vascular disease characterized by capillary-venous cavernomas in the central nervous system. Here the authors show that cavernomas display benign tumor characteristics and originate from the clonal expansion of mutated endothelial progenitors which can attract surrounding wild-type cells, inducing their mesenchymal transition and leading to growth of the cavernoma.

    • Matteo Malinverno
    • Claudio Maderna
    • Elisabetta Dejana
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Vascular endothelium possesses remarkable plasticity in response to cues from its surroundings, leading to great heterogeneity of endothelial cells in different vascular beds. Here the authors explain the molecular basis of endothelial plasticity during embryogenesis and in various diseases.

    • Elisabetta Dejana
    • Karen K. Hirschi
    • Michael Simons
    ReviewsOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • Vascular endothelial-cadherin is a junctional protein implicated in the control of vascular permeability. Orsenigo et al.find that vascular endothelial-cadherin is phosphorylated in veins but not in arteries of mice, and that this sensitizes vessels to rapid changes in permeability in response to inflammatory mediators.

    • Fabrizio Orsenigo
    • Costanza Giampietro
    • Elisabetta Dejana
    ResearchOpen Access
    Nature Communications
    Volume: 3, P: 1-15

  • The transcription factor Sox17 is required for the development of the vasculature in vertebrates. Here Corada et al. show that Sox17 acts downstream of Wnt signalling and upstream of Notch signalling in the regulation of artery and vein differentiation in mice.

    • Monica Corada
    • Fabrizio Orsenigo
    • Elisabetta Dejana
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-14

  • The signalling activity of cell adhesion molecules (CAMs) such as cadherins, immunoglobulin-like CAMs or integrins has been considered a direct consequence of their adhesive properties. However, in some cases CAMs can activate signalling in the absence of cell adhesion, which significantly extends their range of biological activities.

    • Ugo Cavallaro
    • Elisabetta Dejana
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 189-197

  • Leukocyte recruitment from blood to areas of infection is a key step in both innate and adaptive immunological responses. The predominant model has been that leukocytes transmigrate through the junctions between adjacent endothelial cells. However, leukocytes can also migrate through the endothelial cells, and new insights suggest that both caveolae and intermediate filaments are important for this.

    • Elisabetta Dejana
    News & Views
    Nature Cell Biology
    Volume: 8, P: 105-107

  • A role for Sox18 transcription factor has been suggested by lymphatic dysfunction in the human syndrome hypotrichosis-lymphedema-telangiectasia (HLT), which is caused by mutations in Sox18. This paper shows that Sox18 directly activates Prox1 transcription. Sox18-null embryos show a complete absence of Prox1-positive lymphatic endothelial cells emanating from the cardinal vein.

    • Mathias François
    • Andrea Caprini
    • Peter Koopman
    Research
    Nature
    Volume: 456, P: 643-647

  • New blood vessels sprout from existing vasculature to ensure vascularization of developing organs and tissues. A combination of computational modelling and experimental analysis shows that sprout elongation is mediated by differential adhesion dynamics among endothelial cells. The adhesiveness of an individual endothelial cell is governed by VEGF and Notch signalling.

    • E. Dejana
    • M. G. Lampugnani
    News & Views
    Nature Cell Biology
    Volume: 16, P: 305-306

  • Recent studies have elucidated important roles for members of the junctional adhesion molecule (JAM) family in controlling vascular permeability and leukocyte transmigration. Christian Weber and colleagues highlight the role of JAMs as gate keepers in inflammation and vascular pathology.

    • Christian Weber
    • Line Fraemohs
    • Elisabetta Dejana
    Reviews
    Nature Reviews Immunology
    Volume: 7, P: 467-477