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Showing 1–4 of 4 results
Advanced filters: Author: "Elizabeth A. Winzeler" Clear advanced filters
  • Whole-genome sequencing of human malaria parasites has revealed genomic regions that are associated with resistance to artemisinin-based drugs. The findings may help to explain the origin and spread of this worrying trend.

    • A. Taylor Bright
    • Elizabeth A. Winzeler
    News & Views
    Nature
    Volume: 498, P: 446-447
  • Current antimalarial therapy heavily relies on artemisinins, a drug class that only targets the blood stages of the parasite and which is increasingly feared to elicit drug resistance. Flannery, Chatterjee and Winzeler discuss the approaches used to develop novel drugs that are active against different life cycle stages with the ultimate aim of eliminating malaria.

    • Erika L. Flannery
    • Arnab K. Chatterjee
    • Elizabeth A. Winzeler
    Reviews
    Nature Reviews Microbiology
    Volume: 11, P: 849-862
  • To date, most systems-biology research has focused on model organisms such as Saccharomyces cerevisiae, but large amounts of omics data are now beginning to accumulate for many medically relevant microorganisms. Elizabeth Winzeler discusses how systems-biology approaches could help in the search for new drugs and vaccines to treat malaria.

    • Elizabeth A. Winzeler
    Reviews
    Nature Reviews Microbiology
    Volume: 4, P: 145-151