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Showing 1–12 of 12 results
Advanced filters: Author: "Eran Meshorer" Clear advanced filters

  • Reprogramming of somatic cells is an inherently inefficient process. A new study has now identified histone H3K36 methylation as a crucial reprogramming barrier that operates downstream of TGFβ signalling. Global inhibition of H3K36 methylation induced PRC2-dependent silencing of mesenchymal genes and dramatically increased reprogramming efficiency.

    • Lea Rachel Zehava Cohen
    • Eran Meshorer
    News & Views
    Nature Cell Biology
    Volume: 25, P: 1077-1078

  • How traits specific to modern humans have evolved is difficult to study. Here, Gokhman et al. compare measured and reconstructed DNA methylation maps of present-day humans, archaic humans and chimpanzees and find that genes that affect vocal tract and facial anatomy show methylation changes between archaic and modern humans.

    • David Gokhman
    • Malka Nissim-Rafinia
    • Liran Carmel
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-21

  • Two commonly prescribed drugs, statins and aminobisphosphonates, may be helpful in combating the rare aging disorder, Hutchinson-Gilford progeria syndrome (pages 767–772).

    • Eran Meshorer
    • Yosef Gruenbaum
    News & Views
    Nature Medicine
    Volume: 14, P: 713-715

  • Stem-cell differentiation is controlled by RNA processing — as well as by gene expression and transcription. This finding is a milestone towards realizing these cells' potential for research and therapy. See Letter p.241

    • Yair Aaronson
    • Eran Meshorer
    News & Views
    Nature
    Volume: 498, P: 176-177

  • Progerin, a mutated form of lamin A, causes the premature ageing disease Hutchinson-Gilford progeria syndrome and is also involved in normal ageing. Progerin accumulation leads to distinct chromatin-related defects and the NURD complex appears to affect ageing-related chromatin defects.

    • Eran Meshorer
    • Yosef Gruenbaum
    News & Views
    Nature Cell Biology
    Volume: 11, P: 1176-1177

  • Bivalent chromatin domains contain opposing histone modifications that assist cell lineage specification. Two studies report a role for Dppa2 and Dppa4 in the establishment of bivalency and the prevention of de novo DNA methylation at development-related genes in mouse embryonic stem cells.

    • Patrick S. L. Lim
    • Eran Meshorer
    News & Views
    Nature Structural & Molecular Biology
    Volume: 27, P: 685-686

  • The role of RNA splicing in the regulation of stem cell properties has remained largely unexplored. The splicing-associated protein SON is now shown to be necessary for embryonic stem cell maintenance, by influencing the splicing of pluripotency regulators.

    • Ilana Livyatan
    • Eran Meshorer
    News & Views
    Nature Cell Biology
    Volume: 15, P: 1139-1140

  • There is increasing evidence that an 'open' chromatin state contributes to maintenance of pluripotency in stem cells, and that this requires regulation of both the global chromatin state and local repression of transcription. This regulation may also be relevant for chromatin control during reprogramming or during tumorigenesis.

    • Alexandre Gaspar-Maia
    • Adi Alajem
    • Miguel Ramalho-Santos
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 36-47

  • What makes a stem cell is still poorly understood. Recent studies have uncovered that chromatin might hold some of the keys to how embryonic stem cells maintain their pluripotency, their ability to self-renew and induce lineage specification.

    • Eran Meshorer
    • Tom Misteli
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 7, P: 540-546