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Showing 1–2 of 2 results
Advanced filters: Author: "Eric Lai" Clear advanced filters

  • An endogenous small interfering RNA (endo-siRNA) pathway had only previously been characterized in worms. The recent discovery of diverse intramolecular and intermolecular substrates that generate endo-siRNAs in flies and mice raise many questions regarding the biogenesis and function of small regulatory RNAs in animals.

    • Katsutomo Okamura
    • Eric C. Lai
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 9, P: 673-678

  • MicroRNAs exert their regulatory effects by potently repressing some targets, fine-tuning other targets or coordinately regulating target batteries. MicroRNA-mediated control can also be reversible. These regulatory themes underlie the exploitation of microRNA control in diverse biological circuits.

    • Alex S. Flynt
    • Eric C. Lai
    Reviews
    Nature Reviews Genetics
    Volume: 9, P: 831-842