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Showing 1–6 of 6 results
Advanced filters: Author: "Eric N Olson" Clear advanced filters

  • MicroRNAs (miRNAs) are involved in the regulation of gene expression and have been implicated in the pathology of several diseases. Here, van Rooij and Olson discuss the chemistry of current miRNA inhibitors and evaluate miRNAs as potential therapeutic targets for cardiovascular disorders.

    • Eva van Rooij
    • Eric N. Olson
    Reviews
    Nature Reviews Drug Discovery
    Volume: 11, P: 860-872

  • The adult mammalian heart has limited potential for regeneration and repair. Progress has been made in elucidating the cellular processes and regulatory mechanisms involved in heart growth and development, and this can be exploited to restore function in the injured adult heart.

    • Mei Xin
    • Eric N. Olson
    • Rhonda Bassel-Duby
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 14, P: 529-541

  • The link between cytoskeletal actin dynamics and correlated gene activities was unclear. However, the discovery that globular actin polymerization liberates myocardin family transcriptional cofactors to induce serum response factor, which modulates the expression of genes encoding effectors of actin dynamics, has helped bridge this gap in our knowledge.

    • Eric N. Olson
    • Alfred Nordheim
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 11, P: 353-365

  • Genetic and genomic approaches — including high-throughput sequence analysis and transcriptomics experiments — are revealing a clearer picture of the pathophysiological steps underlying the different forms of heart failure (genetic and acquired) and the genomic responses to cardiac overload.

    • Esther E. Creemers
    • Arthur A. Wilde
    • Yigal M. Pinto
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 357-362

  • Long noncoding RNAs (lncRNAs) regulate cellular and tissue function by activating or repressing gene expression. In this Review, Devaux and colleagues summarize the mechanisms by which lncRNAs exert their epigenetic effects, and discuss their role in cardiac development and ageing, with emphasis on the importance of chromatin remodelling. The authors also discuss the potential of lncRNAs to be used as biomarkers and therapeutic agents.

    • Yvan Devaux
    • Jennifer Zangrando
    • Stephane Heymans
    Reviews
    Nature Reviews Cardiology
    Volume: 12, P: 415-425