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Showing 1–5 of 5 results
Advanced filters: Author: "Erwin F. Wagner" Clear advanced filters

  • Connective-tissue cells known as fibroblasts display an increasing spectrum of functions. Different fibroblast subtypes are now shown to either promote or suppress inflammation-associated intestinal cancers.

    • Erwin F. Wagner
    News & Views
    Nature
    Volume: 530, P: 42-43

  • Many people with cancer die from a wasting disorder called cancer-associated cachexia. Two studies in fruit flies show that inhibition of insulin signalling causes cachexia-like organ wasting.

    • Erwin F. Wagner
    • Michele Petruzzelli
    News & Views
    Nature
    Volume: 521, P: 430-431

  • Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) signalling pathways are involved in a vast array of cellular events and are often altered in human cancers. This Review discusses how studies in mouse models have contributed to our understanding of the functions of these pathways in different cancers, and the implications for therapeutic approaches.

    • Erwin F. Wagner
    • Ángel R. Nebreda
    Reviews
    Nature Reviews Cancer
    Volume: 9, P: 537-549

  • Psoriasis is only observed in humans; however, characteristics of the disease, such as prominent epidermal hyperplasia and a distinct inflammatory infiltrate, have been studied in mouse models of psoriasis. In this Review, the authors highlight the mouse models that have contributed to the discovery of novel disease-relevant pathways.

    • Erwin F. Wagner
    • Helia B. Schonthaler
    • Erwin Tschachler
    Reviews
    Nature Reviews Rheumatology
    Volume: 6, P: 704-714