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Showing 1–12 of 12 results
Advanced filters: Author: "Ewan Birney*" Clear advanced filters

  • To be successful, consortia need clear management, codes of conduct and participants who are committed to working for the common good, says ENCODE lead analysis coordinator Ewan Birney.

    • Ewan Birney
    Comments & Opinion
    Nature
    Volume: 489, P: 49-51

  • In the final phase of a seven-year project, the genomes of 2,504 people across five continental regions have been sequenced. The result is a compendium of in-depth data on variation in human populations. See Articles p.68 & p.75

    • Ewan Birney
    • Nicole Soranzo
    News & Views
    Nature
    Volume: 526, P: 52-53

  • A new study presents a comprehensive global analysis of the evolution of segmental duplications in the human genome. The authors identify the origin of ancestral duplication loci, regions of clustered duplicons, and evidence supporting a punctuated model of evolution.

    • Ewan Birney
    News & Views
    Nature Genetics
    Volume: 39, P: 1303-1304

  • The low cost of short-read sequencing has motivated the development of de novo assemblies from only short-read data; impressively, assemblies for large mammalian genomes are now available. However, this is still a developing field, and these de novo assemblies have many artifacts, as do all de novo assemblies.

    • Ewan Birney
    Comments & Opinion
    Nature Methods
    Volume: 8, P: 59-60

  • Adding the first high-quality Neanderthal sequence to genomic comparisons of archaic and modern humans sheds light on gene flow, population structure and adaptation, and suggests the existence of an unknown group. See Article p.43

    • Ewan Birney
    • Jonathan K. Pritchard
    News & Views
    Nature
    Volume: 505, P: 32-33

  • The genomes of 12 fly species have been analysed comparatively. Why should we care? Because sequences that have resisted the selective forces of evolution from fly to human must have functional significance.

    • Ewan Birney
    News & Views
    Nature
    Volume: 450, P: 184-185

  • It has been four years since the original publication of the draft sequence of the rat genome. Five groups are now working together to assemble, annotate and release an updated version of the rat genome. As the prevailing model for physiology, complex disease and pharmacological studies, there is an acute need for the rat's genomic resources to keep pace with the rat's prominence in the laboratory. In this commentary, we describe the current status of the rat genome sequence and the plans for its impending 'upgrade'. We then cover the key online resources providing access to the rat genome, including the new SNP views at Ensembl, the RefSeq and Genes databases at the US National Center for Biotechnology Information, Genome Browser at the University of California Santa Cruz and the disease portals for cardiovascular disease and obesity at the Rat Genome Database.

    • Simon N Twigger
    • Kim D Pruitt
    • Howard J Jacob
    Comments & Opinion
    Nature Genetics
    Volume: 40, P: 523-527