Adenosine signalling has a functional role in many diseases and has long been a target for drug development. However, only one adenosine receptor-specific agent has so far gained approval. Here, Fredholm and colleagues provide an overview of the physiological and pathological functions of adenosine and consider the challenges in the development of compounds targeting adenosine receptors.
- Jiang-Fan Chen
- Holger K. Eltzschig
- Bertil B. Fredholm
