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Showing 1–4 of 4 results
Advanced filters: Author: "Fan Pan" Clear advanced filters

  • Modulation of regulatory T cells (Treg) in the tumour environment is a potential avenue to bolster anti-tumor immunity. Here Liu et al show that perturbation of the negative feedback loop involving STAT1- IFITM3 influences anti-tumor immunity, and that IFITM3 or STAT1 deficiency resulting in the fragility of tumor-infiltrating Treg cells.

    • Xinnan Liu
    • Weiqi Zhang
    • Bin Li
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • SHARPIN acts independently of the ubiquitin-assembly complex LUBAC to attenuate proximal signaling downstream of TCRs by inhibiting the interaction of Zap70 with the TCRζ chain through Lys63 (K63)-linked polyubiquitination. SHARPIN deficiency enhanced TCR signaling and impaired the development and function of Treg cells.

    • Melissa Bowman
    • Fan Pan
    • Edward W Harhaj
    News & Views
    Nature Immunology
    Volume: 17, P: 221-222

  • This Review considers how forkhead box protein P3 (FOXP3) — the key transcription factor of regulatory T (Treg) cells — is regulated both at the transcriptional level and through post-translational modifications. The authors explain how FOXP3 interacts with other molecules to induce and maintain Tregcell populations, and they discuss the potential of therapeutically targeting FOXP3 in the context of human disease.

    • Ling Lu
    • Joseph Barbi
    • Fan Pan
    Reviews
    Nature Reviews Immunology
    Volume: 17, P: 703-717