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Showing 1–5 of 5 results
Advanced filters: Author: "Fanni Gergely" Clear advanced filters

  • Fanni Gergely, Geoffrey Woods and colleagues identify a disease-associated CEP63 mutation in a family with primary microcephaly. They further show that CEP63 and CEP152 interact and form a discrete ring around the proximal end of the parental centriole, implicating this complex in the regulation of centrosome number.

    • Joo-Hee Sir
    • Alexis R Barr
    • Fanni Gergely
    Research
    Nature Genetics
    Volume: 43, P: 1147-1153

  • Long noncoding RNAs (lncRNAs) regulate key steps of cell division. Here, the authors perform a comprehensive RNAi imaging screen targeting more than 2,000 human lncRNAs, and suggest a role of chromatin-associated linc00899 in regulation of cell division by suppressing the transcription of microtubule-binding protein TPPP/p25.

    • Lovorka Stojic
    • Aaron T. L. Lun
    • Fanni Gergely
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-21

  • Centrosome clustering allows survival of cells with amplified centrosomes at the cost of chromosome instability. Here, Chavali et al. show that the centrosome component CEP215 collaborates with the kinesin motor HSET both to maintain spindle poles connections and to cluster centrosomes.

    • Pavithra L. Chavali
    • Gayathri Chandrasekaran
    • Fanni Gergely
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-16

  • Overload of proteasomal clearance triggers formation of a large protein inclusion called the aggresome, which shares similarities with protein aggregates seen in neurodegenerative diseases such as Huntington’s. A new study uncovers how centrosome and centriolar satellite components facilitate stepwise assembly of aggresomes.

    • Elisa Vitiello
    • Fanni Gergely
    News & Views
    Nature Cell Biology
    Volume: 24, P: 408-410