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Showing 1–3 of 3 results
Advanced filters: Author: "Felix Y. Feng" Clear advanced filters
  • Cancer cells often have mutations in anticancer genes that make their survival dependent on other genes. The gene-editing approach CRISPR–Cas9 offers a way to identify such vulnerabilities.

    • Felix Y. Feng
    • Luke A. Gilbert
    News & Views
    Nature
    Volume: 568, P: 463-464
  • Clinical trials have shown that tumours have a modest response to EGFR inhibitors when used alone. Will they prove to be more effective when combined with radiotherapy or chemotherapy or both?

    • Mukesh K. Nyati
    • Meredith A. Morgan
    • Theodore S. Lawrence
    Reviews
    Nature Reviews Cancer
    Volume: 6, P: 876-885
  • The advent of next-generation sequencing technologies has substantially improved our understanding of prostate cancer genetics; however, this knowledge is currently not fully reflected in the form of targeted treatment strategies. In this Review, the authors summarize our current understanding of the genetic landscape of prostate cancer and the challenges to treatment posed by the presence of considerable intratumour and intertumour heterogeneity.

    • Daniel E. Spratt
    • Zachary S. Zumsteg
    • Scott A. Tomlins
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 13, P: 597-610