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Showing 1–5 of 5 results
Advanced filters: Author: "Feng Zhang" Clear advanced filters

  • Eric Lander, Françoise Baylis, Feng Zhang, Emmanuelle Charpentier, Paul Berg and specialists from seven countries call for an international governance framework.

    • Eric S. Lander
    • Françoise Baylis
    • Ernst-Ludwig Winnacker
    Comments & Opinion
    Nature
    Volume: 567, P: 165-168

  • Class 2 CRISPR–Cas systems are characterized by effector modules that consist of a single multidomain protein. In this Analysis, using a computational pipeline, the authors discover three novel families of class 2 effectors that correspond to three new CRISPR–Cas subtypes and present a comprehensive census of class 2 systems that are encoded in complete and draft bacterial and archaeal genomes.

    • Sergey Shmakov
    • Aaron Smargon
    • Eugene V. Koonin
    Research
    Nature Reviews Microbiology
    Volume: 15, P: 169-182

  • Newly emerging techniques will revolutionize our understanding of the mammalian brain. Deisseroth and colleagues detail the development and use of microbial opsins as optogenetic tools for the study of neural circuits and discuss the use of these tools as potential future therapies for neurological disorders.

    • Feng Zhang
    • Alexander M. Aravanis
    • Karl Deisseroth
    Reviews
    Nature Reviews Neuroscience
    Volume: 8, P: 577-581

  • CRISPR–Cas9 has been adopted as a powerful genome-editing technology in various species. By generating libraries of thousands of guide RNAs — which direct the Cas9 nuclease to chosen genomic loci — high-throughput genetic perturbations are now possible. This Review discusses the latest applications of CRISPR–Cas9 in mammalian functional genomics screens. It covers related genome-scale applications of Cas9 for either gene knockout or transcriptional modulation, and provides comparisons with complementary RNA interference (RNAi)-based approaches.

    • Ophir Shalem
    • Neville E. Sanjana
    • Feng Zhang
    Reviews
    Nature Reviews Genetics
    Volume: 16, P: 299-311

  • Recent years have seen several important advances in the tools available to interrogate the function of specific genes. Here, Heidenreich and Zhang describe the advantages of the precise and efficient CRISPR–Cas9 (clustered regularly interspaced short palindromic repeat–CRISPR-associated protein) system for gene editing and outline how this approach may benefit research into nervous system function and disease.

    • Matthias Heidenreich
    • Feng Zhang
    Reviews
    Nature Reviews Neuroscience
    Volume: 17, P: 36-44