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Showing 1–3 of 3 results
Advanced filters: Author: "Filip K. Swirski" Clear advanced filters

  • Inflammation is a recognized component of many diseases, including atherosclerosis and its complications. IL-1β is a crucial cytokine promoting the inflammatory cascade. In the February 2017 issue of Nature Medicine, Furman et al. show that metabolites can trigger inflammation via inflammasome-dependent IL-1β production in elderly individuals. Intriguingly, caffeine is protective by offsetting this activation.

    • Filip K. Swirski
    • Matthias Nahrendorf
    News & Views
    Nature Reviews Cardiology
    Volume: 14, P: 194-196

  • Plaques are lipid-rich structures in the blood-vessel wall that can cause heart attacks or strokes if they rupture. It now seems that blood-cell fragments called platelets alter the function of immune cells in ways that accelerate plaque formation.

    • Filip K. Swirski
    News & Views
    Nature
    Volume: 577, P: 323-324

  • In 2017, a cluster of papers have provided strong evidence in favour of the inflammation hypothesis in cardiovascular disease. From fundamental observations on clonal haematopoiesis to clinical evidence indicating that blocking an inflammatory cytokine mitigates heart disease, 2017 has been a watershed year.

    • Filip K. Swirski
    News & Views
    Nature Reviews Cardiology
    Volume: 15, P: 79-80