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Showing 1–5 of 5 results
Advanced filters: Author: "Florence Apparailly" Clear advanced filters

  • Like the mythical eagle devouring Prometheus's liver as fast as it regrew, chronic inflammation hinders cartilage regeneration in inflammatory arthritis. Using stem cells engineered to secrete anti-inflammatory molecules in response to local inflammatory factors could provide a way to keep the eagle at bay as the stem cells differentiate into chondrocytes.

    • Florence Apparailly
    News & Views
    Nature Reviews Rheumatology
    Volume: 13, P: 516-518

  • Small interfering RNAs (siRNAs) are a useful experimental tool to silence gene activity. The challenge, however, remains to optimize delivery and imbue 'drug-like' properties to siRNAs for therapeutic use. Here, the authors discuss advances in siRNA therapeutics and their potential application in treating rheumatic disease.

    • Florence Apparailly
    • Christian Jorgensen
    Reviews
    Nature Reviews Rheumatology
    Volume: 9, P: 56-62

  • Several microRNAs (miRNAs) that are involved in the regulation of cellular metabolism or immune processes are deregulated in patients with rheumatic diseases, such as rheumatoid arthritis or osteoarthritis. These small inhibitory molecules offer considerable potential for the treatment of these disorders, but a multidisciplinary approach is needed to limit their potential adverse effects through, for example, improved specificity and delivery.

    • Rita Vicente
    • Danièle Noël
    • Christian Jorgensen
    Reviews
    Nature Reviews Rheumatology
    Volume: 12, P: 211-220