Intestinal fibrosis is a common and potentially serious complication of IBD. The traditional view that the development of fibrosis in these patients is inevitable and irreversible is progressively changing with improved understanding of the pathogenic mechanisms of fibrosis. This Review discusses the complex general mechanisms of fibrosis and addresses specific issues related to intestinal fibrosis in the setting of IBD, including the potential implications of novel treatments.
- Florian Rieder
- Claudio Fiocchi
