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Showing 1–2 of 2 results
Advanced filters: Author: "Florian Stengel" Clear advanced filters

  • While the role of specific posttranslational modifications (PTMs) is increasingly well understood for core histones, this is not the case for linker histone H1. Here the authors show that site-specific ubiquitylation of H1 results in distinct interactomes, regulates phase separation, and modulates assembly of chromatosomes.

    • Eva Höllmüller
    • Simon Geigges
    • Florian Stengel
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Oncoprotein E6 facilitates the E6AP-catalyzed ubiquitination of p53. Here, the authors study the structural basis of this process by qualitative and quantitative cross-linking mass spectrometry, providing insights into E6AP-E6-p53 complex assembly and the conformational dynamics that enable p53 ubiquitination.

    • Carolin Sailer
    • Fabian Offensperger
    • Florian Stengel
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12