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Showing 1–2 of 2 results
Advanced filters: Author: "Francis de Zegher" Clear advanced filters
  • Evidence indicates that flutamide, a specific and potent androgen-receptor blocker, when given in low dose (∼1 mg/kg daily), confers a first-choice balance between antiandrogenic efficacy and hepatic safety for women and adolescent girls with hirsutism or other androgen-related symptoms.

    • Francis de Zegher
    • Lourdes Ibáñez
    News & Views
    Nature Reviews Endocrinology
    Volume: 6, P: 421-422
  • Hyperinsulinaemic androgen excess leads to hirsutism, acne, seborrhoea and irregular menstrual cycles in young women. In this Perspectives article, Ibáñez and colleagues hypothesize that hyperinsuliaemic androgen excess arises owing to increased lipid load in adipose tissue, outline potential diagnostic criteria, and discuss the advantages and disadvantages of different treatment options for girls with this disorder.

    • Lourdes Ibáñez
    • Ken K. Ong
    • Francis de Zegher
    Reviews
    Nature Reviews Endocrinology
    Volume: 10, P: 499-508