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Showing 1–7 of 7 results
Advanced filters: Author: "Frank Heppner" Clear advanced filters

  • SARS-CoV-2 infection is associated with various neurological effects both during and after infection. In this Review, Meinhardt and colleagues discuss the possible impact of SARS-CoV-2 infection on different cell populations of the nervous system and the neurological alterations that result, thus facilitating the development of treatment options.

    • Jenny Meinhardt
    • Simon Streit
    • Frank L. Heppner
    Reviews
    Nature Reviews Neuroscience
    Volume: 25, P: 30-42

  • Proinflammatory cytokine expression increases as a result of amyloid deposition in Alzheimer's disease. Frank L. Heppner and colleagues show that genetic and pharmacological inhibition of IL-12 and IL-23 signaling reduces plaque load and improves cognitive deficits in mouse models of Alzheimer's disease. As the concentration of p40 is also increased in the cerebrospinal fluid of individuals with Alzheimer's disease, this suggests that this pathway may be targeted therapeutically in patients.

    • Johannes vom Berg
    • Stefan Prokop
    • Frank L Heppner
    Research
    Nature Medicine
    Volume: 18, P: 1812-1819

  • It is now emerging that the neuroinflammation that is associated with Alzheimer disease may have a key role in driving this disease. In this Review, Heppner, Ransohoff and Becher examine the contribution of the immune system to the pathogenesis of this disorder.

    • Frank L. Heppner
    • Richard M. Ransohoff
    • Burkhard Becher
    Reviews
    Nature Reviews Neuroscience
    Volume: 16, P: 358-372