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Showing 1–2 of 2 results
Advanced filters: Author: "Frank J. Gonzalez" Clear advanced filters

  • Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that are involved in regulating glucose and lipid homeostasis, inflammation, proliferation and differentiation. This Review discusses the roles of PPARs in cancer and focuses on PPARβ/δ and the controversies yet to be resolved.

    • Jeffrey M. Peters
    • Yatrik M. Shah
    • Frank J. Gonzalez
    Reviews
    Nature Reviews Cancer
    Volume: 12, P: 181-195

  • The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best known for mediating the toxicity and tumour-promoting properties of dioxin. AHR levels are increased with constitutive nuclear localization in many tumours. How might AHR facilitate tumour progression, and can it be therapeutically modulated?

    • Iain A. Murray
    • Andrew D. Patterson
    • Gary H. Perdew
    Reviews
    Nature Reviews Cancer
    Volume: 14, P: 801-814