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Showing 1–6 of 6 results
Advanced filters: Author: "Frank J. Slack" Clear advanced filters

  • MicroRNAs (miRNAs) are small non-coding RNAs that can modulate mRNA expression. Insights into the roles of miRNAs in development and disease have led to the development of new therapeutic approaches that are based on miRNA mimics or agents that inhibit their functions (antimiRs), and the first such approaches have entered the clinic. This Review discusses the role of different miRNAs in cancer and other diseases, and provides an overview of current miRNA therapeutics in the clinic.

    • Rajesha Rupaimoole
    • Frank J. Slack
    Reviews
    Nature Reviews Drug Discovery
    Volume: 16, P: 203-222

  • Finding biologically relevant targets is a prerequisite for understanding the function of any trans regulator of gene expression, but this can be particularly challenging with microRNAs (miRNAs). A study in this issue addresses the problem by identifying a novel mode of miRNA target recognition.

    • Giovanni Stefani
    • Frank J Slack
    News & Views
    Nature Structural & Molecular Biology
    Volume: 19, P: 265-266

  • A new strategy is presented to functionally knock down microRNAs in a mouse.

    • Pedro P Medina
    • Frank J Slack
    News & Views
    Nature Methods
    Volume: 6, P: 37-38

  • Embryonic stem cells can create copies of themselves, but can also mature into almost any type of cell in the body. Tiny gene regulators called microRNAs are now shown to have a role in directing these properties.

    • Frank J. Slack
    News & Views
    Nature
    Volume: 463, P: 616

  • Many different microRNAs (miRNAs) have now been linked to cancer, but our understanding of the pathways that are regulated by these miRNAsin vivois still limited. This Review discusses progress in using mouse models to understand the roles of miRNAs in cancer and the therapeutic potential of these molecules.

    • Andrea L. Kasinski
    • Frank J. Slack
    Reviews
    Nature Reviews Cancer
    Volume: 11, P: 849-864

  • Non-coding RNAs (ncRNAs) are functional molecules that regulate physiological programmes in developmental and disease contexts. This Review article discusses the complex networks of interactions that ncRNAs engage in and how these confer oncogenic or tumour-suppressive effects in cancer.

    • Eleni Anastasiadou
    • Leni S. Jacob
    • Frank J. Slack
    Reviews
    Nature Reviews Cancer
    Volume: 18, P: 5-18