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Showing 1–7 of 7 results
Advanced filters: Author: "Frank L. van de Veerdonk" Clear advanced filters

  • Little is known about the regulatory mechanisms of antifungal host defense. Two complementary studies show that the E3 ubiquitin ligase CBLB targets dectin-1 and dectin-2 for degradation, and thus exerts a strong anti-inflammatory effect.

    • Frank L van de Veerdonk
    • Mihai G Netea
    News & Views
    Nature Medicine
    Volume: 22, P: 834-835

  • The cell-surface receptor TREML4 amplifies cellular responses to single-stranded RNA by regulating recruitment of the adaptor MyD88 to the receptor TLR7. Mice lacking TREML4 show impaired antiviral immunity but also reduced severity of lupus-like disease.

    • Mihai G Netea
    • Frank L van de Veerdonk
    News & Views
    Nature Immunology
    Volume: 16, P: 445-446

  • Aspergillus fumigatusis an environmental fungus that can cause life-threatening disease. In this Review, van de Veerdonk and colleagues describe howA. fumigatusadapts to environmental change, mechanisms of host defence and our current knowledge of the interplay between the host immune response and the fungus.

    • Frank L. van de Veerdonk
    • Mark S. Gresnigt
    • Jean-Paul Latgé
    Reviews
    Nature Reviews Microbiology
    Volume: 15, P: 661-674

  • This Review describes the host immune response toCandida fungal infections. The authors detail the innate and adaptive immune mechanisms, as well as the non-immune mechanisms, that are involved in the antifungal response. They also discuss emerging evidence suggesting that both innate and adaptive immune cells contribute to immune memory against Candidaspecies.

    • Mihai G. Netea
    • Leo A. B. Joosten
    • Frank L. van de Veerdonk
    Reviews
    Nature Reviews Immunology
    Volume: 15, P: 630-642

  • Sepsis — which is caused by a dysregulated host response to infection — is a life-threatening organ dysfunction. This Review describes the recent advances in our understanding of sepsis pathogenesis and discusses strategies for the development of successful therapies.

    • Tom van der Poll
    • Frank L. van de Veerdonk
    • Mihai G. Netea
    Reviews
    Nature Reviews Immunology
    Volume: 17, P: 407-420

  • Candida albicanscan grow as unicellular budding yeast cells and as filamentous hyphae. Mihai Netea and colleagues discuss the molecular mechanisms that drive this dimorphism, the changes that lead to differential interaction with the host, and the immunological mechanisms that discriminate between tissue colonization and invasion.

    • Neil A. R. Gow
    • Frank L. van de Veerdonk
    • Mihai G. Netea
    Reviews
    Nature Reviews Microbiology
    Volume: 10, P: 112-122