The immunomodulatory effects of mesaconate and citraconate, naturally occurring isomers of the immunomodulatory metabolite itaconate, are investigated. Mesaconate is shown to be derived from itaconate, and citraconate is shown to inhibit ACOD1 and display stronger NRF2 agonism.
- F. Chen
- W. A. M. Elgaher
- F. Pessler