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Showing 1–3 of 3 results
Advanced filters: Author: "Frank-Erik De Leeuw" Clear advanced filters

  • Poststroke dementia is a clinically heterogeneous syndrome with various underlying mechanisms. A better understanding of the pathophysiology of poststroke dementia together with an improved ability to differentiate between various dementia syndromes will be useful for optimizing therapeutic interventions, and for informing patients and carers about treatment options and prognosis.

    • Anil M. Tuladhar
    • Frank-Erik de Leeuw
    News & Views
    Nature Reviews Neurology
    Volume: 6, P: 63-64

  • The incidence of Parkinson disease (PD) increases with age, so age-related conditions are expected to feature prominently among the comorbidities associated with this disease. In this article, Nanhoe-Mahabier et al. explore a possible link between PD and cerebrovascular disease, discussing the pathophysiological mechanisms that could underlie such a relationship, and considering how comorbid cerebrovascular disease might affect the clinical presentation of PD.

    • Wandana Nanhoe-Mahabier
    • Karlijn F. de Laat
    • Bastiaan R. Bloem
    Reviews
    Nature Reviews Neurology
    Volume: 5, P: 533-541

  • The average age of ischaemic stroke onset is decreasing, owing to a rise in the incidence of stroke among individuals under 50 years of age. In this article, the authors review the current literature on risk factors for and aetiology of 'young' ischaemic stroke. In addition, they discuss the lifelong implications of stroke in young adults, not only in terms of cardiovascular disease recurrence, but also with respect to psychosocial consequences, including cognitive and social impairments, mood disorders and fatigue.

    • Noortje A. M. M. Maaijwee
    • Loes C. A. Rutten-Jacobs
    • Frank-Erik de Leeuw
    Reviews
    Nature Reviews Neurology
    Volume: 10, P: 315-325