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Showing 1–6 of 6 results
Advanced filters: Author: "Freddy Radtke" Clear advanced filters

  • In this Review, Nowell and Radtke outline the accumulating evidence that Notch functions as a tumour suppressor in a range of cancers, and present potential mechanisms by which loss of Notch signalling could promote tumorigenesis.

    • Craig S. Nowell
    • Freddy Radtke
    Reviews
    Nature Reviews Cancer
    Volume: 17, P: 145-159

  • Notch signalling has well-described roles in lymphocyte development. More recently, it has become apparent that Notch is also crucial for innate immune cells and for mature lymphocyte responses. Here, the authors discuss our current understanding of how Notch contributes to both innate and adaptive immune responses.

    • Freddy Radtke
    • H. Robson MacDonald
    • Fabienne Tacchini-Cottier
    Reviews
    Nature Reviews Immunology
    Volume: 13, P: 427-437