The soil nematodeCaenorhabditis elegans is easy to manipulate genetically and is therefore a useful model organism. But C. elegansdoes not use its Toll-like receptor homologue for immune defence. So what can it tell us about the origins and functions of other immune defence pathways in higher organisms?
- Javier E. Irazoqui
- Jonathan M. Urbach
- Frederick M. Ausubel