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Showing 1–2 of 2 results
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  • A new imaging and spectroscopy approach combines the ability of magnetic resonance imaging to manipulate nuclear spins with the high sensitivity of γ-ray detection, enabling a greatly reduced number of nuclei to be used compared to conventional NMR signal detection.

    • Yuan Zheng
    • G. Wilson Miller
    • Gordon D. Cates
    Research
    Nature
    Volume: 537, P: 652-655

  • Recent studies have identified frequent inactivating mutations in different SWI/SNF subunits in several types of cancer, highlighting the tumour suppressor roles of these chromatin remodellers. This Review discusses the current knowledge regarding inactivating mutations, and silencing, of SWI/SNF subunits in cancer, the molecular mechanisms of their tumour suppressor functions and possibilities for therapeutic intervention in SWI/SNF-mutant cancers.

    • Boris G. Wilson
    • Charles W. M. Roberts
    Reviews
    Nature Reviews Cancer
    Volume: 11, P: 481-492