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Showing 1–4 of 4 results
Advanced filters: Author: "G. Martin" Clear advanced filters

  • The calpains are a conserved family of cysteine proteinases that catalyse the controlled proteolysis of many specific substrates that are involved in proliferation, apoptosis and migration. Calpain expression is altered during tumorigenesis and can influence the response to cancer therapies, indicating a need for new calpain inhibitors.

    • Sarah J. Storr
    • Neil O. Carragher
    • Stewart G. Martin
    Reviews
    Nature Reviews Cancer
    Volume: 11, P: 364-374

  • Congenital diarrhoeal disorders (CDDs) represent an evolving web of rare chronic enteropathies, with a typical onset early in life. The number of well-characterized disorders attributed to CDDs has gradually increased over the past few years and this Review highlights new CDD entities and advances understanding of functionally related genes that are opening new diagnostic and therapeutic perspectives.

    • Roberto Berni Canani
    • Giuseppe Castaldo
    • Olivier Goulet
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 12, P: 293-302

  • Twin studies have long been used for dissecting the relative contributions of genetics and other factors to various phenotypes. This Review discusses how these traditional studies are now being integrated with modern omics technologies to provide a wide range of biological insights.

    • Jenny van Dongen
    • P. Eline Slagboom
    • Dorret I. Boomsma
    Reviews
    Nature Reviews Genetics
    Volume: 13, P: 640-653

  • The genetic interactions that pattern the embryonic telencephalon are highly complex. Fishell and Hébert bring clarity to these events by describing the key genetic interactions that underlie the patterning of the early telencephalon into distinct proliferative zones.

    • Jean M. Hébert
    • Gord Fishell
    Reviews
    Nature Reviews Neuroscience
    Volume: 9, P: 678-685