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Showing 1–5 of 5 results
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  • What factors direct the formation of heart muscle in the developing embryo? Unexpectedly, a chromatin-remodelling protein complex turns out to be a crucial determinant of cardiac-cell fate.

    • Fu-Sen Liang
    • Gerald R. Crabtree
    News & Views
    Nature
    Volume: 459, P: 654-655
  • Recent genome-sequencing studies in human neurodevelopmental and psychiatric disorders have revealed mutations in chromatin-modifying enzymes, such as chromatin remodellers and histone-modifying enzymes. Such studies are improving our understanding of the roles of these modifiers in human neurodevelopment, and this article discusses the emerging roles for several of these enzymes in development and disease.

    • Jehnna L. Ronan
    • Wei Wu
    • Gerald R. Crabtree
    Reviews
    Nature Reviews Genetics
    Volume: 14, P: 347-359
  • In multicellular organisms, the identity of a cell is determined by its unique gene expression pattern, which is remembered and passed on to daughter cells by epigenetic mechanisms. Recent technical advances are enabling researchers to look at how epigenetic changes are coordinated on a genome-wide scale, thus giving rise to a new field of epigenomics.

    • Dustin E. Schones
    • Keji Zhao
    Reviews
    Nature Reviews Genetics
    Volume: 9, P: 179-191
  • The process of autophagy has recently sparked great interest as it is recognized to be involved in a wide range of diseases. The prospect of its manipulation for therapeutic purposes has led to the discovery of many exciting new potential drug targets.

    • David C. Rubinsztein
    • Jason E. Gestwicki
    • Daniel J. Klionsky
    Reviews
    Nature Reviews Drug Discovery
    Volume: 6, P: 304-312
  • Genome-scale methods are providing increasingly detailed views of nucleosome organization and chromatin structure. This is enhancing our understanding of how DNA-based reactions occur in the context of chromatin and how they are influenced by genome accessibility.

    • Oliver Bell
    • Vijay K. Tiwari
    • Dirk Schübeler
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 554-564