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Showing 1–2 of 2 results
Advanced filters: Author: "George D. Smith" Clear advanced filters

  • Synaptic transmission is temporally and spatially tightly regulated to serve the needs of fast information flow in the nervous system. Lisman and colleagues bridge the synaptic cleft and review the sequence of pre- and postsynaptic events of quantal release.

    • John E. Lisman
    • Sridhar Raghavachari
    • Richard W. Tsien
    Reviews
    Nature Reviews Neuroscience
    Volume: 8, P: 597-609

  • The protein kinase C (PKC) family of highly related protein kinases are implicated in several diseases and have been a major focus of drug discovery efforts. However, no single drug specifically targeting a PKC isozyme has yet received approval. Here, Mochly-Rosen and colleagues review the efforts, challenges and opportunities in developing PKC modulators.

    • Daria Mochly-Rosen
    • Kanad Das
    • Kevin V. Grimes
    Reviews
    Nature Reviews Drug Discovery
    Volume: 11, P: 937-957