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Showing 1–6 of 6 results
Advanced filters: Author: "George Davey Smith" Clear advanced filters

  • Replication is not enough. Marcus R. Munafò and George Davey Smith state the case for triangulation.

    • Marcus R. Munafò
    • George Davey Smith
    Comments & Opinion
    Nature
    Volume: 553, P: 399-401

  • The evidence for prostate cancer screening using prostate-specific antigen with reference to UK criteria is presented. Such screening might result in considerable over-diagnosis and over-treatment of clinically insignificant prostate cancer. Morbidity associated with treatment of suspected prostate cancer is substantial, so the likelihood of harm may outweigh the prospect of benefit.

    • Richard M Martin
    • George Davey Smith
    • Jenny Donovan
    Reviews
    Nature Clinical Practice Oncology
    Volume: 2, P: 538-539

  • Initial randomized trials of cholesteryl ester transfer protein (CETP) inhibitors were terminated early owing to adverse effects or futility. The REVEAL trial now shows the benefit of CETP inhibition in coronary heart disease. Despite raising HDL-cholesterol levels, the cardiovascular effect of CETP inhibitors is probably due to lowering of non-HDL-cholesterol levels.

    • Michael V. Holmes
    • George Davey Smith
    News & Views
    Nature Reviews Cardiology
    Volume: 14, P: 635-636

  • Mark McCarthy and colleagues report a genome-wide association study of birth weight. They identified two loci, in ADCY5 and near CCNL1, that are associated with birth weight and explain 0.3% and 0.1% of the variance in birth weight, respectively.

    • Rachel M Freathy
    • Dennis O Mook-Kanamori
    • Mark I McCarthy
    Research
    Nature Genetics
    Volume: 42, P: 430-435

  • Mendelian randomization (MR) is an increasingly common tool that involves the use of genetic variants to evaluate causal relationships between exposures and outcomes. In this Review, Holmes et al. describe some of the scenarios in which findings from MR analyses can be challenging to evaluate, using examples from studies on cardiometabolic diseases.

    • Michael V. Holmes
    • Mika Ala-Korpela
    • George Davey Smith
    Reviews
    Nature Reviews Cardiology
    Volume: 14, P: 577-590