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Showing 1–4 of 4 results
Advanced filters: Author: "Gideon Bollag" Clear advanced filters

  • After three decades of unsuccessful efforts to develop small molecules that neutralize the cancer-causing Ras proteins, an approach has been found that opens up fresh avenues for anticancer research. See Letter p.548

    • Gideon Bollag
    • Chao Zhang
    News & Views
    Nature
    Volume: 503, P: 475-476

  • Comprehensive studies of the kinome set the stage for discovering the next generation of kinase-directed drugs.

    • Chao Zhang
    • Gaston Habets
    • Gideon Bollag
    News & Views
    Nature Biotechnology
    Volume: 29, P: 981-983

  • Ras genes are the most common targets for somatic gain-of-function mutations in human cancer. Germline mutations that affect components of the Ras signalling pathway were shown to cause several developmental disorders. What are the implications of germline mutations in the Ras pathway for our understanding of normal developmental processes and cancer pathogenesis?

    • Suzanne Schubbert
    • Kevin Shannon
    • Gideon Bollag
    Reviews
    Nature Reviews Cancer
    Volume: 7, P: 295-308

  • Vemurafenib is a small-molecule inhibitor of the oncogenic BRAF kinase approved for the treatment of melanoma. Here, the scientists involved in the discovery of vemurafenib describe the underlying biology of BRAF, the technology used to identify vemurafenib and its clinical development milestones, along with future prospects based on lessons learned during its development.

    • Gideon Bollag
    • James Tsai
    • Peter Hirth
    Reviews
    Nature Reviews Drug Discovery
    Volume: 11, P: 873-886