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Showing 1–12 of 12 results
Advanced filters: Author: "Giorgio Trinchieri" Clear advanced filters

  • In this Viewpoint article,Nature Reviews Immunologyasks five experts in the field to share their thoughts on the development and immune functions of plasmacytoid dendritic cells. Importantly, will these cells be a useful clinical target?

    • Boris Reizis
    • Marco Colonna
    • Michel Gilliet
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 558-565

  • The ability of NKG2D to trigger costimulation in CD8+ T cells and cytotoxicity in NK cells is thought to arise from its differential association with the intracellular signaling molecules DAP10 and DAP12, respectively. This model has now been refined to include the ability of DAP10 to mediate cytotoxic signals.

    • Giorgio Trinchieri
    News & Views
    Nature Immunology
    Volume: 4, P: 509-510

  • Four new papers focused on how interleukin 10–producing cells are induced have led to some unexpected and intriguing observations on the nature of interleukin 17–producing T helper cells.

    • Dragana Jankovic
    • Giorgio Trinchieri
    News & Views
    Nature Immunology
    Volume: 8, P: 1281-1283

  • Dendritic cell subsets are thought to become committed to the dendritic cell lineage once they have differentiated from lymphoid or myeloid lineage precursors. However, this tenet has been challenged by data showing plasticity among the different subsets.

    • Anne O'Garra
    • Giorgio Trinchieri
    News & Views
    Nature Immunology
    Volume: 5, P: 1206-1208

  • Plasmacytoid dendritic cells express the microRNA miR-126, which controls their survival and effector functions via the receptor VEGFR2.

    • Marina Cella
    • Giorgio Trinchieri
    News & Views
    Nature Immunology
    Volume: 15, P: 8-9

  • DAP12-coupled receptors influence signals emanating from Toll-like receptors, integrins and receptors for cytokines and growth factors. New findings indicate that DAP12 also facilitates the ability of CSF-1R, the receptor for M-CSF, to induce the stabilization and nuclear translocation of β-catenin.

    • Daniel W McVicar
    • Giorgio Trinchieri
    News & Views
    Nature Immunology
    Volume: 10, P: 681-683

  • Recent evidence indicates that the intestinal microbiota has important functions in maintaining intestinal homeostasis through crosstalk with the innate immune system. However, changes in the intestinal microbiota or breakdown of this crosstalk can result in colitis and colitis-associated colorectal cancer.

    • Maya Saleh
    • Giorgio Trinchieri
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 9-20

  • The human microbiota influences a whole range of physiological functions. In this Review, Roy and Trinchieri discuss our current understanding of how the gut microbiota modulates responses to cancer therapy as well as mediating susceptibility to toxic side effects.

    • Soumen Roy
    • Giorgio Trinchieri
    Reviews
    Nature Reviews Cancer
    Volume: 17, P: 271-285

  • Emerging evidence indicates that the induction of an effective immune response involves the cooperation of multiple Toll-like receptors and other pattern-recognition receptors. Here, the role of this cooperation in host defence against various pathogens and the therapeutic implications are discussed.

    • Giorgio Trinchieri
    • Alan Sher
    Reviews
    Nature Reviews Immunology
    Volume: 7, P: 179-190