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Showing 1–4 of 4 results
Advanced filters: Author: "Giovanni B. Frisoni" Clear advanced filters

  • Since the launch ofNature Clinical Practice Neurologyin 2005, we have seen remarkable progress in many areas of neurology research, but what does the future hold? For this special Viewpoint article, we invited a panel of Advisory Board members and other journal contributors to outline their research priorities and predictions for the next 10 years.

    • Ralf Baron
    • Donna M. Ferriero
    • Michael Weller
    Reviews
    Nature Reviews Neurology
    Volume: 11, P: 658-664

  • Alzheimer disease features neurobiological changes long before the first symptoms of cognitive decline. Results from a new study to define the orderly changes of markers of amyloidosis and neurodegeneration over the disease course will assist the development of biomarker-based protocols for early diagnosis, and disease-modifying drugs.

    • Giovanni B. Frisoni
    News & Views
    Nature Reviews Neurology
    Volume: 8, P: 299-300

  • Suspected non-Alzheimer disease pathophysiology (SNAP) is a biomarker-based concept that applies to individuals with normal levels of amyloid-β biomarkers in the brain, but in whom biomarkers of neurodegeneration are abnormal. Clinically normal and mildly impaired individuals with SNAP are at increased risk of poor clinical and cognitive outcomes. In this Perspectives article, Clifford Jack and colleagues describe the available data on SNAP and address topical controversies in the field.

    • Clifford R. Jack Jr
    • David S. Knopman
    • Stephanie J. B. Vos
    Reviews
    Nature Reviews Neurology
    Volume: 12, P: 117-124

  • Functional and structural connectivity measures, assessed by means of functional and diffusion MRI, are emerging as potential intermediate biomarkers for Alzheimer disease and other neurodegenerative disorders. In this article, Pievani et al. evaluate the evidence that connectivity biomarkers are associated downstream with clinical phenotypes and topographic brain imaging markers of neurodegeneration, and upstream with molecular determinants of neurodegeneration and susceptibility genes.

    • Michela Pievani
    • Nicola Filippini
    • Giovanni B. Frisoni
    Reviews
    Nature Reviews Neurology
    Volume: 10, P: 620-633