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Showing 1–3 of 3 results
Advanced filters: Author: "Gwendalyn J Randolph" Clear advanced filters

  • Recent elegant studies in the mouse have increased our understanding of the origin and function of different macrophage and dendritic cell populations. However, these studies have also highlighted an old debate — how exactly should we classify the cells of the mononuclear phagocyte system? Here, five experts give their thoughts on this topic.

    • Frédéric Geissmann
    • Siamon Gordon
    • Gwendalyn J. Randolph
    Reviews
    Nature Reviews Immunology
    Volume: 10, P: 453-460

  • Macrophages accumulate in atherosclerotic lesions during the inflammation that is part of atherosclerosis development and progression. A new study in mice indicates that the accumulation of macrophages in atherosclerotic plaques depends on local macrophage proliferation rather than the recruitment of circulating monocytes (pages 1166–1172).

    • Gwendalyn J Randolph
    News & Views
    Nature Medicine
    Volume: 19, P: 1094-1095

  • Monocytes not only serve as precursors for macrophages, but also contribute to tissue immunity by presenting antigen to T cells and producing immunomodulatory mediators. In this Review, the authors discuss some of these less well-appreciated immune functions of monocytes.

    • Claudia V. Jakubzick
    • Gwendalyn J. Randolph
    • Peter M. Henson
    Reviews
    Nature Reviews Immunology
    Volume: 17, P: 349-362