The TYRO3, AXL and MERTK (TAM) family of receptor tyrosine kinases (RTKs) are overexpressed in tumour cells, promoting cell survival and chemoresistance. These RTKs also function in normal innate immune cells to promote an immunosuppressive tumour microenvironment. Thus, TAM RTKs are implicated as dual therapeutic targets in cancer.
- Douglas K. Graham
- Deborah DeRyckere
- H. Shelton Earp
