Methotrexate-associated lymphoproliferative disorders are rare conditions mostly observed in patients receiving immunosuppression therapy. Tran and coauthors report the first documented case of methotrexate-associated mantle-cell lymphoma in a 75-year-old patient with myasthenia gravis. After cessation of methotrexate, the patient was treated with anthracycline-based combination chemoimmunotherapy and maintenance rituximab therapy and achieved complete remission. The authors discuss the management options for patients with methotrexate-associated mantle-cell lymphoma.
- Huy Tran
- Catherine Cheung
- Maher K Gandhi