Hyperactivation of phosphatidylinositol 3-kinase (PI3K) signalling cascades is one of the most common events in human cancers. This Review discusses recent advances in our knowledge of the roles of distinct PI3K isoforms in normal and oncogenic signalling, and the current state and future potential of targeting this pathway in the clinic.
- Lauren M. Thorpe
- Haluk Yuzugullu
- Jean J. Zhao