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Showing 1–7 of 7 results
Advanced filters: Author: "Hans-Gustaf Ljunggren" Clear advanced filters

  • New findings show that a subpopulation of mucosal RORγt+ cells expresses natural killer cell receptors and produces interleukin 22. These innate immune cells may be pivotal in maintaining mucosal homeostasis.

    • Karl-Johan Malmberg
    • Hans-Gustaf Ljunggren
    News & Views
    Nature Immunology
    Volume: 10, P: 11-12

  • Natural killer cells were so named because of their ability to lyse tumour cells. Although initial studies have provided encouraging results, several challenges remain in optimizing the use of NK cells in therapeutic settings, as is described in this Review.

    • Hans-Gustaf Ljunggren
    • Karl-Johan Malmberg
    Reviews
    Nature Reviews Immunology
    Volume: 7, P: 329-339

  • A key regulator of the balance of signals that activate effector mechanisms versus those that restrain them, β-arrestin 2 mediates the inhibition of natural killer cell cytotoxicity.

    • Yenan T Bryceson
    • Hans-Gustaf Ljunggren
    News & Views
    Nature Immunology
    Volume: 9, P: 835-836

  • In this Review, the authors describe the diversity and characteristics of tissue-resident human natural killer cells, with focus on those found in the liver, uterus and lungs. They also discuss important unresolved questions and future challenges in the field.

    • Niklas K. Björkström
    • Hans-Gustaf Ljunggren
    • Jakob Michaëlsson
    Reviews
    Nature Reviews Immunology
    Volume: 16, P: 310-320

  • Each tissue in our body contains a unique microenvironment that can differentially shape immune reactivity. In this Review article, Shiet al. describe how organ-specific factors influence natural killer cell homing and phenotype, and discuss the local molecular and cellular interactions that determine the protective or pathogenic functions of natural killer cells in the different tissues.

    • Fu-Dong Shi
    • Hans-Gustaf Ljunggren
    • Luc Van Kaer
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 658-671

  • Although the MHC class II-mediated modulation of CD4+ T cell responses is typically associated with dendritic cells, macrophages and B cells, other cell populations are also suggested to show such behaviour. The authors discuss these atypical antigen-presenting cells and question their relevance to immune responses in vivo.

    • Taku Kambayashi
    • Terri M. Laufer
    Reviews
    Nature Reviews Immunology
    Volume: 14, P: 719-730