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Showing 1–2 of 2 results
Advanced filters: Author: "Hao Yin" Clear advanced filters

  • Genome editing has emerged as an attractive approach to therapeutically manipulate gene expression. Here, Anderson and colleagues provide an overview of genome-editing platforms, focusing on the methods and challenges of intracellular biomacromolecule delivery. Preclinical and clinical trials involving genome-editing technologies are also discussed.

    • Hao Yin
    • Kevin J. Kauffman
    • Daniel G. Anderson
    Reviews
    Nature Reviews Drug Discovery
    Volume: 16, P: 387-399

  • This Review introduces the biological barriers to gene deliveryin vivoand discusses recent advances in material sciences, nanotechnology and nucleic acid chemistry that have yielded promising non-viral systems for the delivery of DNA, mRNA, small interfering RNAs and microRNAs, some of which are currently undergoing testing in clinical trials.

    • Hao Yin
    • Rosemary L. Kanasty
    • Daniel G. Anderson
    Reviews
    Nature Reviews Genetics
    Volume: 15, P: 541-555