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Showing 1–5 of 5 results
Advanced filters: Author: "Haruhiko Koseki" Clear advanced filters

  • Atopic dermatitis is an inflammatory skin disease featuring systemic involvement. Here authors show that the two major clinical manifestations of the disease, erythema and papulation, are distinguished by differential interplay between local skin and systemic immunity, uncovered by integrated transcriptomics.

    • Aiko Sekita
    • Hiroshi Kawasaki
    • Haruhiko Koseki
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Here the authors show that a Polycomb Repressive Complex 1 (PRC1) containing PCGF1 prevents excessive loading of transcriptional activators and chromatin remodelers on nascent DNA, allowing proper deposition of nucleosomes immediately after the passage of the DNA replication fork to optimize downstream chromatin configurations in hematopoietic stem and progenitor cells (HSPCs).

    • Junichiro Takano
    • Shinsuke Ito
    • Tomokatsu Ikawa
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • Polycomb repressive complexes (PRC1 and PRC2) repress genes that are crucial for development via epigenetic modifications; however, their role in differentiation is not well known. Here the authors reveal that a PCGF1-containing PRC1 variant facilitates exit from pluripotency by downregulating target genes and recruiting PRC2.

    • Hiroki Sugishita
    • Takashi Kondo
    • Haruhiko Koseki
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Inheritance of Polycomb repressive complex 2 (PRC2)-mediated gene silencing involves self-propagation of histone H3 lysine 27 (H3K27) methylation from an initial nucleation site, but how the first H3K27 methylation marks are established is not fully understood. A recent study reveals that PRC2 can reconstitute H3K27 methylation de novo in cells that have lost the mark. This reconstitution is dependent on the PRC2 core component SUZ12, which provides a novel link between initiation and self-propagation of this critical epigenetic mark.

    • Jafar Sharif
    • Haruhiko Koseki
    News & Views
    Nature Structural & Molecular Biology
    Volume: 25, P: 197-199