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Showing 1–2 of 2 results
Advanced filters: Author: "Heather R. Christofk" Clear advanced filters

  • Mutations in the enzyme isocitrate dehydrogenase lead to the accumulation of a metabolite that seems to promote cancer by influencing the epigenetic status of cells. But the effects are reversible, hinting at therapeutic targets.

    • Abigail S. Krall
    • Heather R. Christofk
    News & Views
    Nature
    Volume: 496, P: 38-40

  • Tumours reprogram their metabolism to maximize macromolecule biosynthesis for growth. However, which of the common tumour-associated metabolic activities are critical for proliferation remains unclear. Glutamate-derived glutamine is now shown to satisfy the glutamine needs of glioblastoma, indicating that glutamine anaplerosis is dispensable for growth.

    • Abigail S. Krall
    • Heather R. Christofk
    News & Views
    Nature Cell Biology
    Volume: 17, P: 1515-1517