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Showing 1–4 of 4 results
Advanced filters: Author: "Hector Peinado" Clear advanced filters

  • Extracellular vesicles, such as exosomes, are important effectors in the formation of tumour-fostering niches. Pigmented melanosomes are now shown to have a relevant role in establishing a tumour niche in primary melanoma by reprogramming dermal fibroblasts into cancer-associated fibroblasts through the transfer of miR-211.

    • Susana García-Silva
    • Héctor Peinado
    News & Views
    Nature Cell Biology
    Volume: 18, P: 911-913

  • Hypoxia is a critical factor during tumour progression, regulating the expression of multiple factors implicated in tumour growth, epithelial to mesenchymal transition (EMT) and invasive cell behaviour. We now learn that the EMT inducer Twist operates under the control of hypoxia signalling in the tumour microenvironment.

    • Héctor Peinado
    • Amparo Cano
    News & Views
    Nature Cell Biology
    Volume: 10, P: 253-254

  • This Review summarizes the natural progression of pre-metastatic niche formation and evolution, highlighting recent advances and future hurdles.

    • Héctor Peinado
    • Haiying Zhang
    • David Lyden
    Reviews
    Nature Reviews Cancer
    Volume: 17, P: 302-317

  • This article reviews how the identification of Snail, ZEB and some basic helix–loop–helix (bHLH) factors as inducers of epithelial–mesenchymal transition (EMT) and potent repressors of E cadherin expression has opened new avenues for cancer research with potential clinical implications.

    • Héctor Peinado
    • David Olmeda
    • Amparo Cano
    Reviews
    Nature Reviews Cancer
    Volume: 7, P: 415-428