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Showing 1–3 of 3 results
Advanced filters: Author: "Helen X Chen" Clear advanced filters

  • Antiangiogenic agents that target the VEGF pathway have become an important part of standard therapy in multiple cancer indications. Although most adverse effects of VEGF inhibitors are modest and manageable, some are associated with serious and life-threatening consequences. This Review examines the toxicity profiles of anti-VEGF monoclonal antibodies and small-molecule inhibitors and considers the potential mechanisms of the adverse effects, risk factors, and the implications for patient management.

    • Helen X. Chen
    • Jessica N. Cleck
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 6, P: 465-477

  • A key issue in anticancer drug development is how best to select and evaluate potential combinations of the rapidly growing number of molecularly targeted drugs. Dancey and Chen consider development strategies for targeted-agent combinations, highlighting challenges for their rational preclinical and clinical evaluation, and discussing possible approaches to overcoming them.

    • Janet E. Dancey
    • Helen X. Chen
    Reviews
    Nature Reviews Drug Discovery
    Volume: 5, P: 649-659

  • Developing optimal combination strategies for molecularly targeted anticancer drugs is substantially more complex than for traditional chemotherapies. Here, Doroshow and colleagues discuss the lessons learned from the evaluation of combinations of molecularly targeted anticancer agents by the US National Cancer Institute (NCI), and highlight several new approaches that the NCI has initiated to improve the effectiveness of such combinations.

    • Shivanni Kummar
    • Helen X. Chen
    • James H. Doroshow
    Reviews
    Nature Reviews Drug Discovery
    Volume: 9, P: 843-856