This study investigates the role of c-Abelson (c-Abl) kinase in neutrophil extracellular trap (NET) formation and inflammation during sepsis. The authors demonstrate that c-Abl kinase plays a pivotal role in NET formation, pulmonary formation of CXC chemokines and lung injury in sepsis. Authors conclude that targeting c-Abl kinase might be a useful strategy to ameliorate local and systemic inflammation in sepsis.
- Avin Hawez
- Zhiyi Ding
- Henrik Thorlacius