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Showing 1–7 of 7 results
Advanced filters: Author: "Henrik Kaessmann" Clear advanced filters

  • Evolutionary study of long noncoding RNA (lncRNA) repertoires and expression patterns in 11 tetrapod species identifies approximately 11,000 primate-specific lncRNAs and 2,500 highly conserved lncRNAs, including approximately 400 genes that are likely to have ancient origins; many lncRNAs, particularly ancient ones, are actively regulated and may function mainly in embryonic development.

    • Anamaria Necsulea
    • Magali Soumillon
    • Henrik Kaessmann
    Research
    Nature
    Volume: 505, P: 635-640

  • Using high-throughput genome and transcriptome sequencing, Y chromosome evolution across 15 representative mammals is explored, with results providing evidence for three independent sex chromosome originations in mammals and birds.

    • Diego Cortez
    • Ray Marin
    • Henrik Kaessmann
    Research
    Nature
    Volume: 508, P: 488-493

  • Alexandre Reymond, Henrik Kaessman and colleagues report a high-resolution survey of copy number variation in mice and assess the impact of such variation on gene expression across multiple tissues and strains. They conclude that CNVs substantially influence global transcription, including long-range cis effects extending up to several hundred kilobases.

    • Charlotte N Henrichsen
    • Nicolas Vinckenbosch
    • Alexandre Reymond
    Research
    Nature Genetics
    Volume: 41, P: 424-429

  • Gene duplication can occur via insertion of reverse transcribed mRNAs into the genome. Although originally thought to be non-functional, recent studies have uncovered how these retrocopies can acquire novel functions, and how patterns of retroposition can give unexpected insights into genome evolution.

    • Henrik Kaessmann
    • Nicolas Vinckenbosch
    • Manyuan Long
    Reviews
    Nature Reviews Genetics
    Volume: 10, P: 19-31

  • This Review provides insights obtained from comparative transcriptomic studies of mammalian species. The dynamics of gene expression evolution in coding and non-coding genes, as well as the regulatory basis of transcriptome evolution and future research avenues, are discussed.

    • Anamaria Necsulea
    • Henrik Kaessmann
    Reviews
    Nature Reviews Genetics
    Volume: 15, P: 734-748