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Showing 1–4 of 4 results
Advanced filters: Author: "Hidde L Ploegh" Clear advanced filters

  • Toll-like receptors (TLRs) have a central role in the initiation of innate and adaptive immune responses. Recent studies have shown that various accessory molecules are required for the biosynthesis and/or activation of several TLRs. A detailed knowledge of these accessory molecules is necessary to better understand the function of TLRs in the immune system.

    • Clarissa C. Lee
    • Ana M. Avalos
    • Hidde L. Ploegh
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 168-179

  • The pathways of antigen processing and presentation are well known, but how do antigens gain access to MHC molecules in dendritic cells and what is the role of autophagy, endoplasmic reticulum dislocation and Toll-like receptors in these pathways?

    • Jatin M. Vyas
    • Annemarthe G. Van der Veen
    • Hidde L. Ploegh
    Reviews
    Nature Reviews Immunology
    Volume: 8, P: 607-618

  • Toll-like receptors respond to ligands embedded in pathogen-derived macromolecules to induce immune responses. Binding of a stimulatory ligand to preexisting dimers of Toll-like receptor 9 induces conformational changes that lead to their full activation.

    • You-Me Kim
    • Melanie M Brinkmann
    • Hidde L Ploegh
    News & Views
    Nature Immunology
    Volume: 8, P: 675-677