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Showing 1–7 of 7 results
Advanced filters: Author: "Holger Stark" Clear advanced filters

  • The proteasome regulates several important cellular processes and has been identified as a target for therapeutic interventions. Here the authors map the conformational and energy landscape of the 26S proteasome upon Oprozomib binding and uncover long-range allosteric effects that control the dynamic behaviour of the proteasome.

    • David Haselbach
    • Jil Schrader
    • Holger Stark
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8

  • Microswimmers in a fluid are an example of an active suspension whereby the system is driven out of equilibrium though the interaction of the microswimmers with their surrounding environment. Here, the authors study the orientational microstructure of active suspensions in a viscoelastic fluid and show how the activity of the microswimmers can alter the bulk properties.

    • Akash Choudhary
    • Sankalp Nambiar
    • Holger Stark
    ResearchOpen Access
    Communications Physics
    Volume: 6, P: 1-11

  • Recent technological advances with cryo-electron microscopy (cryo-EM) — a biophysical technique that can be used to determine the structure of biological macromolecules and assemblies — have raised hopes that it might soon become an important tool for drug discovery, particularly for 'intractable' targets that are still not accessible to analysis by X-ray crystallography. This article describes these advances and critically assesses their relevance for drug discovery.

    • Jean-Paul Renaud
    • Ashwin Chari
    • Christian Wiesmann
    Reviews
    Nature Reviews Drug Discovery
    Volume: 17, P: 471-492

  • The investigation of microswimmer dynamics provides key insights in the design of active microfluidic systems and opens doors for further studies on inertial active matter. The authors establish a theoretical foundation for the dynamics of microswimmers in confined microflows with finite fluid inertia and demonstrate non-trivial impact of inertia in a microchannel flow.

    • Akash Choudhary
    • Subhechchha Paul
    • Holger Stark
    ResearchOpen Access
    Communications Physics
    Volume: 5, P: 1-9