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Showing 1–2 of 2 results
Advanced filters: Author: "Hongbo Zhang" Clear advanced filters

  • Despite delivering gene-specific silencing, the use of deoxyribozymes (DNAzymes) for cancer therapy is limited by toxicity due to off-target effects. Here, the authors develop a multi-component DNAzyme, targeting both miRNA21 and HSP70, to induce tumour-specific sensitisation to photothermal therapy in preclinical models of pancreatic cancer.

    • Jiaqi Yan
    • Xiaodong Ma
    • Hongbo Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • Changes in protein or histone acetylation are key integrators of physiological processes such as the circadian clock, cell cycle and gene regulation. In this Review, the authors describe the role of reversible acetylation in metabolic control and how these processes contribute to adaptive cellular and organismal homeostasis. The potential for modulating these pathways as a treatment for various metabolic diseases is also discussed.

    • Keir J. Menzies
    • Hongbo Zhang
    • Johan Auwerx
    Reviews
    Nature Reviews Endocrinology
    Volume: 12, P: 43-60