Ferroptosis is involved in the pathogenesis of several human diseases and targeted inhibition of ferroptosis is promising for their clinical treatment. Here, the authors report the synthesis of ultrasmall poly(acrylic) acid coated Mn3O4 nanoparticles that can act as mimics of antioxidant enzymes and scavenge reactive oxygen species, as well as potently suppress ferroptosis.
- Xinyi Shan
- Jiahuan Li
- Hao Wu