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Showing 1–6 of 6 results
Advanced filters: Author: "Howard Y Chang" Clear advanced filters

  • The ways in which an RNA molecule folds to form structures can be crucial to its function, and so methods for studying RNA structures make an important contribution to understanding transcriptomes. Experimental approaches in this field are being advanced by coupling them to high-throughput sequencing.

    • Yue Wan
    • Michael Kertesz
    • Howard Y. Chang
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 641-655

  • Long non-coding RNAs (lncRNAs) are a class of RNAs with great molecular and regulatory diversity. This Review discusses how, beyond their lack of protein-coding potential, some types of lncRNAs are known to exhibit features that are distinct from mRNAs, including their transcriptional regulation, localization, processing, biological capabilities and degradation. Such properties underlie many of the key cellular functions of lncRNAs.

    • Jeffrey J. Quinn
    • Howard Y. Chang
    Reviews
    Nature Reviews Genetics
    Volume: 17, P: 47-62

  • The repurposing of a bacterial defence system known as CRISPR into a potent activator of gene expression in human cells enables powerful studies of gene function, as exemplified in cancer cells. See Article p.583

    • Seung Woo Cho
    • Howard Y. Chang
    News & Views
    Nature
    Volume: 517, P: 560-562

  • The discovery of long non-coding RNAs that control the liaisons between a transcription factor with a key role in prostate cancer and its target genes sheds light on how RNAs dictate information flow in the cell nucleus. See Letter p.598

    • Adam M. Schmitt
    • Howard Y. Chang
    News & Views
    Nature
    Volume: 500, P: 536-537

  • Polycomb/Trithorax response elements (PRE/TREs) are genetic elements that can stably silence or activate genes. A new study describes how long noncoding RNAs (lncRNAs) transcribed from opposite strands of the Drosophila melanogaster vestigial PRE/TRE throw the switch between these two opposing epigenetic states.

    • Jeffrey J Quinn
    • Howard Y Chang
    News & Views
    Nature Genetics
    Volume: 46, P: 929-931

  • Introducing four genes into mouse skin fibroblasts reprograms these cells into embryonic stem cells. If similar techniques work in human cells, patient-specific stem cells for tissue engineering and cell-based therapies may be closer to reality.

    • Howard Y Chang
    • George Cotsarelis
    News & Views
    Nature Medicine
    Volume: 13, P: 783-784